Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats

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Permanent URL	http://hdl.lib.byu.edu/1877/2034
Title	Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats
BYU Creator	Lephart, Edwin D. Bu, Lihong H.
Creator	Setchell, Kenneth
Keywords	isoflavones; soy; phytoestrogens; 17beta-estradiol
Description/Abstract	Background: Isoflavones, the most abundant phytoestrogens in soy foods, are structurally similar to 17beta-estradiol. Few studies have examined the nociception and stress hormone responses after consumption of soy isoflavones. Methods: In this study, ovariectomized (OVX) female Long-Evans rats were fed either an isoflavone-rich diet (Phyto-600) or an isoflavone-free diet (Phyto-free). We examined the effects of soy isoflavones on metabolism by measuring body weights, food/water intake, adipose tissue weights as well as serum leptin levels. Also, circulating isoflavone levels were quantified. During chemically induced estrous, nociceptive thresholds were recorded. Then, the animals were subjected to a stressor and stress hormone levels were quantified. Results Body weights were significantly lower in Phyto-600 fed rats compared to Phyto-free values within one week and during long-term consumption of soy isoflavones. Correspondingly, Phyto-600 fed animals displayed significantly less adipose deposition and lower serum leptin levels than Phyto-free values. However, rats on the Phyto-600 diet displayed greater food/water intake compared to Phyto-free levels. No changes in thermal pain threshold or stress hormone levels (ACTH and corticosterone) were observed after activation of the hypothalamic-pituitary-adrenal (HPA) stress axis. Conclusion: In summary, these data show that consumption of soy isoflavones 1) increases metabolism, demonstrated by significantly decreased body weights, adipose tissue deposition and leptin levels, but 2) does not alter nociception or stress hormone responses, as indexed by thermal pain threshold, serum corticosterone and ACTH levels in chemically-induced estrous OVX rats.
Source	Reproductive Biology and Endocrinology, Vol. 3, No. 1. (2005);
Publisher	BioMed Central
Date Original	2005-10-26
Language	English eng en
Publication Type	Articles
Type	Text
Format	application/pdf
Owning Institution	Brigham Young University
BYU College	College of Life Sciences
BYU Department	Physiology and Developmental Biology
Copyright Status	(c) 2005 Bu et al; licensee BioMed Central Ltd.;
Copyright Use Information	http://www.lib.byu.edu/generic_copyright.html

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Influences of dietary soy isoflavones on metabolism but not nociception and stress hormone responses in ovariectomized female rats

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